Publications

Below is a presentation of current publications relevant to ART procedure outcomes associated with use of ZyMōt devices for sperm sample preparation. These publications are categorized according to the ART procedures outcomes topics shown to facilitate review of the literature by topic.

ART Procedure Outcomes
ART Procedure Outcomes
Centrifugation / density gradient centrifugation
Clinical pregnancy
DNA fragmentation / genomic integrity
Embryo euploidy
Fertilization / blastulation
IUI outcome
Patient outcome
Reactive oxygen species (ROS) / cellular stress
Centrifugation / density gradient centrifugation

MICROFLUIDIC-BASED DEVICE SELECTS SPERM WITH LESS DNA DAMAGE AND HIGHER MOTILITY, WHAT ELSE?

Pardiñas ML.1, De los Santos JM.2, Viloria T.2, Ortega-Jaen D.1, Martin A.1, Rivera-Egea R.2, De los Santos MJ.1,2, 1IVI Foundation-IIS La Fe, Research and Innovation, Valencia, Spain, 2IVI RMA Valencia, IVF Laboratory, Valencia, Spain.

ASSESSING THE INTEGRITY OF THE MALE GAMETE GENOME TO IMPROVE ART CLINICAL OUTCOMES

Kocur OM., Xie P., Sung C., Souness S., Rosenwaks Z., Palermo GD., Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, New York, New York USA

FERTILIZATION RATE AND EMBRYONIC DEVELOPMENT AFTER INTRACYTOPLASMIC SPERM INJECTION USING A MICROFLUIDIC SPERM SELECTION DEVICE WITHOUT CENTRIFUGATION

Haruhisa Tsuji1, Hiroya Kitasaka1, Noritaka Fukunaga1,2 and Yoshimasa Asada1,2 1 Asada Ladies Clinic, Aichi, Japan, 2 Asada Institute for Reproductive Medicine, Aichi, Japan

DOES ZYMOT SPERM SEPARATION IMPROVE EMBRYO DEVELOPMENT OUTCOMES WHEN APPLIED TO ALL INFERTILITY PATIENTS COMPARED TO DENSITY GRADIENT WASHING OR SURGICALLY ATTAINED SPERM?

Mitchel C. Schiewe, MS, PhD, Ahmad Morsi Abu Maizar, M.Sc, Melanie Nordbak, BS, Michelle Alcoer, BS, Andrew W. Dinsmore, BS, Claudia De Romana, BS, Pedro J. Toledo, BS, Kelly Baek, MD, Guy E. Ringler, MD, Korine Chung, MD, Richard Marrs, MD California Fertility Partners, Los Angeles, CA

MICROFLUIDIC SORTING SELECTS SPERM FOR CLINICAL USE WITH REDUCED DNA DAMAGE

Quinn M. M., Jalalian L., Ribeiro S., et al. Human Reproduction, Volume 33, Issue 8, August 2018, Pages 1388–1393

SPERM DNA FRAGMENTATION (SDF) WAS MOST EFFECTIVELY IMPROVED BY A SPERM SEPARATION DEVICE COMPARED TO DIFFERENT GRADIENT AND SWIMUP METHODS

Broussard A., Leader B., Tirado E. et al. Fertility and Sterility. April 2019 Volume 111, Issue 4, Supplement, Page e15

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Clinical pregnancy

MICROFLUIDIC SPERM SELECTION DEVICE INCREASES CLINICAL PREGNANCY RATE IN IVF/PGT-A CYCLES

C.Z. Berton1, I. Yoshida1, P. Carvalho1, R. Souza1, L.D.C. Onoda1, E.B. Cordts2, C.P. Barbosa2. 1Instituto Ideia Fértil de Saúde Reprodutiva, Embryology, São Paulo, Brazil, 2 Instituto Ideia Fértil de Saúde Reprodutiva, Gynecology, São Paulo, Brazil.

MACS Vs MICROFLUIDICS SPERM SORTING FOR RAISED SPERM DFI - A RCT

Durga Rao, Krishna Chaitanya M., Oasis Fertility – Hyderabad, India

COMPARISON OF MICROFLUID SPERM SORTING CHIP AND DENSITY GRADIENT METHODS FOR USE IN INTRAUTERINE INSEMINATION CYCLES

Gode, F., Bodur T., Güntürkün F., et al. Fertility and Sterility. Volume 112, Issue 5, November 2019, Pages 842-848.e1

UTILIZING SPERMATOZOA WITH THE HIGHEST GENOMIC INTEGRITY ENHANCES ICSI OUTCOME.

Keating, D., Tavares, D., Rosenwaks, Z., Palermo, G. Fertility and Sterility Vol. 116, E67-E68(2021)

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DNA fragmentation / genomic integrity

GENOTYPIC SPERM SORTING: A LESS INVASIVE “ART” TO PREVENT GENETIC DISORDERS IN NEWBORNS

*1,3Olumide O. Adenmosun, PhD, MBA (oadenmos@fau.edu) 2Waseem Asghar, PhD, 3Michael Matilsky, PhD, HCLD and 1James Kumi-Diaka, DVM, PhD, 1Florida Atlantic University, Biological Sciences, Davie, USA, 2Florida Atlantic University, Electrical Engineering and Computer Science, Boca Raton, USA, 3Boca Fertility, Andrology/Embryology Laboratory, Boca Raton, USA

MICROFLUIDIC-BASED DEVICE SELECTS SPERM WITH LESS DNA DAMAGE AND HIGHER MOTILITY, WHAT ELSE?

Pardiñas ML.1, De los Santos JM.2, Viloria T.2, Ortega-Jaen D.1, Martin A.1, Rivera-Egea R.2, De los Santos MJ.1,2, 1IVI Foundation-IIS La Fe, Research and Innovation, Valencia, Spain, 2IVI RMA Valencia, IVF Laboratory, Valencia, Spain.

ASSESSING THE INTEGRITY OF THE MALE GAMETE GENOME TO IMPROVE ART CLINICAL OUTCOMES

Kocur OM., Xie P., Sung C., Souness S., Rosenwaks Z., Palermo GD., Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, New York, New York USA

MALE AGE IS ASSOCIATED WITH SPERM DNA INTEGRITY: SELECTION OF HIGH DNA INTEGRITY SPERM BY MICROFLUIDICS SORTING IS CRITICAL TO CLINICAL OUTCOMES IN OLDER PATIENTS

Nami Morishita, Megumi Miura, Yuki Kobayashi, Rie Matsunaga, Tomoko Maeda, Masanori Ochi, Toshitaka Horiuchi, Ochi Yume Clinic Nagoya, Nagoya, Japan

MACS Vs MICROFLUIDICS SPERM SORTING FOR RAISED SPERM DFI - A RCT

Durga Rao, Krishna Chaitanya M., Oasis Fertility – Hyderabad, India

A TREATMENT APPROACH FOR COUPLES WITH DISRUPTED SPERM DNA INTEGRITY AND RECURRENT ART FAILURE.

Alessandra Parrella, Derek Keating, Stephanie Cheung, Philip Xie, Joshua D. Stewart, Zev Rosenwaks, Gianpiero D. Palermo Journal of Assisted Reproduction and Genetics volume 36, pages2057–2066 (2019)

A TREATMENT APPROACH FOR COUPLES WITH DISRUPTED SPERM DNA INTEGRITY AND RECURRENT ART FAILURE

Parrella, A., Keating, D., Cheung, S. et al. J Assist Reprod Genet 36, 2057–2066 (2019)

MICROFLUIDIC SPERM SEPARATION DEVICE DRAMATICALLY LOWERS DFI

Cohen,1A. Bastuba,2P. Campbell. 3 1Male Fertility and Sexual Medicine Specialists, San Diego, CA, USA; 2Fertility Center of California, San Diego, CA, USA; 3 Department of Urology, Naval Medical Center San Diego, San Diego, CA, USA.

DOES ZYMOT SPERM SEPARATION IMPROVE EMBRYO DEVELOPMENT OUTCOMES WHEN APPLIED TO ALL INFERTILITY PATIENTS COMPARED TO DENSITY GRADIENT WASHING OR SURGICALLY ATTAINED SPERM?

Mitchel C. Schiewe, MS, PhD, Ahmad Morsi Abu Maizar, M.Sc, Melanie Nordbak, BS, Michelle Alcoer, BS, Andrew W. Dinsmore, BS, Claudia De Romana, BS, Pedro J. Toledo, BS, Kelly Baek, MD, Guy E. Ringler, MD, Korine Chung, MD, Richard Marrs, MD California Fertility Partners, Los Angeles, CA

SPERM DNA FRAGMENTATION AND FUNCTIONAL FEATURES OF HUMAN SPERM SELECTED BY MICROFLUIDIC SORTING FOR CLINICAL USE

Nami Morishita, Ph.D., Natsumi Hyogo, M.A., Yukari Kurasaki, B.A., Rio Sakuma, M.A., Hiromi Morita, M.A., Megumi Miura, M.A, Yuki Kobayashi, B.A., Rie Matsunaga, M.A., Tomoko Maeda, Ph.D., Hiroshi Makino, Ph.D., Masanori Ochi, Ph.D., Toshitaka Horiuchi, Ph.D. OCHI YUME CLINIC NAGOYA, Nagoya, Japan

CAN MICROFLUIDIC SPERM SORTING HELP SEPARATION OF SPERMS WITH GOOD QUALITY DNA?

Krishna Mantravadi, Sr. MBBS, PGDHOM, Masters in clinical embryology, Durga Gedela Rao, Sr. MRCOG Oasis fertility, Hyderabad, India

SELECTION OF FUNCTIONAL HUMAN SPERM WITH HIGHER DNA INTEGRITY AND FEWER REACTIVE OXYGEN SPECIES

Asghar W., Velasco V., Kingsley J.L., et al. Advanced Healthcare Materials. Volume 3, Issue 10, October, 2014

UTILIZING SPERMATOZOA WITH THE HIGHEST GENOMIC INTEGRITY ENHANCES ICSI OUTCOME.

Keating, D., Tavares, D., Rosenwaks, Z., Palermo, G. Fertility and Sterility Vol. 116, E67-E68(2021)

A SPERM SELECTION TECHNIQUE TO IMPROVE EMBRYO PLOIDY.

Keating, D., Tavares, D., Rosenwaks, Z., Palermo, G. Fertility and Sterility Vol. 116, P-53(2021)

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Embryo euploidy

A TREATMENT APPROACH FOR COUPLES WITH DISRUPTED SPERM DNA INTEGRITY AND RECURRENT ART FAILURE.

Alessandra Parrella, Derek Keating, Stephanie Cheung, Philip Xie, Joshua D. Stewart, Zev Rosenwaks, Gianpiero D. Palermo Journal of Assisted Reproduction and Genetics volume 36, pages2057–2066 (2019).

A TREATMENT APPROACH FOR COUPLES WITH DISRUPTED SPERM DNA INTEGRITY AND RECURRENT ART FAILURE

Parrella, A., Keating, D., Cheung, S. et al. J Assist Reprod Genet 36, 2057–2066 (2019)

DOES MICROFLUIDIC SPERM SORTING IMPROVE EMBRYO DEVELOPMENT AND EUPLOIDY RATES IN PATIENTS UNDERGOING ICSI?

Alex Robles, M.D.,1 Evan Akiva Reshef, MD,1 Robert W. Prosser, MSc,1Eric J. Forman, M.D.,2 Zev Williams, M.D., PhD.1 1Columbia University Fertility Center, New York, NY; 2Columbia University Fertility Center.

DOES ZYMOT SPERM SEPARATION IMPROVE EMBRYO DEVELOPMENT OUTCOMES WHEN APPLIED TO ALL INFERTILITY PATIENTS COMPARED TO DENSITY GRADIENT WASHING OR SURGICALLY ATTAINED SPERM?

Mitchel C. Schiewe, MS, PhD, Ahmad Morsi Abu Maizar, M.Sc, Melanie Nordbak, BS, Michelle Alcoer, BS, Andrew W. Dinsmore, BS, Claudia De Romana, BS, Pedro J. Toledo, BS, Kelly Baek, MD, Guy E. Ringler, MD, Korine Chung, MD, Richard Marrs, MD California Fertility Partners, Los Angeles, CA

UTILIZING SPERMATOZOA WITH THE HIGHEST GENOMIC INTEGRITY ENHANCES ICSI OUTCOME.

Keating, D., Tavares, D., Rosenwaks, Z., Palermo, G. Fertility and Sterility Vol. 116, E67-E68(2021)

A SPERM SELECTION TECHNIQUE TO IMPROVE EMBRYO PLOIDY.

Keating, D., Tavares, D., Rosenwaks, Z., Palermo, G. Fertility and Sterility Vol. 116, P-53(2021)

View More
Fertilization / blastulation

FERTILIZATION RATE AND EMBRYONIC DEVELOPMENT AFTER INTRACYTOPLASMIC SPERM INJECTION USING A MICROFLUIDIC SPERM SELECTION DEVICE WITHOUT CENTRIFUGATION

Haruhisa Tsuji1, Hiroya Kitasaka1, Noritaka Fukunaga1,2 and Yoshimasa Asada1,2 1 Asada Ladies Clinic, Aichi, Japan, 2 Asada Institute for Reproductive Medicine, Aichi, Japan

DOES MICROFLUIDIC SPERM SORTING IMPROVE EMBRYO DEVELOPMENT AND EUPLOIDY RATES IN PATIENTS UNDERGOING ICSI?

Alex Robles, M.D.,1 Evan Akiva Reshef, MD,1 Robert W. Prosser, MSc,1Eric J. Forman, M.D.,2 Zev Williams, M.D., PhD.1 1Columbia University Fertility Center, New York, NY; 2Columbia University Fertility Center.

DOES ZYMOT SPERM SEPARATION IMPROVE EMBRYO DEVELOPMENT OUTCOMES WHEN APPLIED TO ALL INFERTILITY PATIENTS COMPARED TO DENSITY GRADIENT WASHING OR SURGICALLY ATTAINED SPERM?

Mitchel C. Schiewe, MS, PhD, Ahmad Morsi Abu Maizar, M.Sc, Melanie Nordbak, BS, Michelle Alcoer, BS, Andrew W. Dinsmore, BS, Claudia De Romana, BS, Pedro J. Toledo, BS, Kelly Baek, MD, Guy E. Ringler, MD, Korine Chung, MD, Richard Marrs, MD California Fertility Partners, Los Angeles, CA

SPERM DNA FRAGMENTATION AND FUNCTIONAL FEATURES OF HUMAN SPERM SELECTED BY MICROFLUIDIC SORTING FOR CLINICAL USE

Nami Morishita, Ph.D., Natsumi Hyogo, M.A., Yukari Kurasaki, B.A., Rio Sakuma, M.A., Hiromi Morita, M.A., Megumi Miura, M.A, Yuki Kobayashi, B.A., Rie Matsunaga, M.A., Tomoko Maeda, Ph.D., Hiroshi Makino, Ph.D., Masanori Ochi, Ph.D., Toshitaka Horiuchi, Ph.D. OCHI YUME CLINIC NAGOYA, Nagoya, Japan

UTILIZING SPERMATOZOA WITH THE HIGHEST GENOMIC INTEGRITY ENHANCES ICSI OUTCOME.

Keating, D., Tavares, D., Rosenwaks, Z., Palermo, G. Fertility and Sterility Vol. 116, E67-E68(2021)

View More
IUI outcome

COMPARISON OF MICROFLUID SPERM SORTING CHIP AND DENSITY GRADIENT METHODS FOR USE IN INTRAUTERINE INSEMINATION CYCLES

Gode, F., Bodur T., Güntürkün F., et al. Fertility and Sterility. Volume 112, Issue 5, November 2019, Pages 842-848.e1

View More
Patient outcome

OPTIMIZING SPERM SELECTION AND REPRODUCTIVE OUTCOMES BY MICROFLUIDICS FOR COUPLES WITH RAISED DFI

G. Gedela, Durga Rao, Krishna Chaitanya M., Oasis Fertility – Hyderabad, India

MALE AGE IS ASSOCIATED WITH SPERM DNA INTEGRITY: SELECTION OF HIGH DNA INTEGRITY SPERM BY MICROFLUIDICS SORTING IS CRITICAL TO CLINICAL OUTCOMES IN OLDER PATIENTS

Nami Morishita, Megumi Miura, Yuki Kobayashi, Rie Matsunaga, Tomoko Maeda, Masanori Ochi, Toshitaka Horiuchi, Ochi Yume Clinic Nagoya, Nagoya, Japan

A TREATMENT APPROACH FOR COUPLES WITH DISRUPTED SPERM DNA INTEGRITY AND RECURRENT ART FAILURE

Parrella, A., Keating, D., Cheung, S. et al. J Assist Reprod Genet 36, 2057–2066 (2019)

UTILIZING SPERMATOZOA WITH THE HIGHEST GENOMIC INTEGRITY ENHANCES ICSI OUTCOME.

Keating, D., Tavares, D., Rosenwaks, Z., Palermo, G. Fertility and Sterility Vol. 116, E67-E68(2021)

View More
Reactive oxygen species (ROS) / cellular stress

MICROFLUIDIC SPERM SEPARATION DEVICE DRAMATICALLY LOWERS DFI

Cohen,1A. Bastuba,2P. Campbell. 3 1Male Fertility and Sexual Medicine Specialists, San Diego, CA, USA; 2Fertility Center of California, San Diego, CA, USA; 3 Department of Urology, Naval Medical Center San Diego, San Diego, CA, USA.

SELECTION OF FUNCTIONAL HUMAN SPERM WITH HIGHER DNA INTEGRITY AND FEWER REACTIVE OXYGEN SPECIES

Asghar W., Velasco V., Kingsley J.L., et al. Advanced Healthcare Materials. Volume 3, Issue 10, October, 2014

SPERM DNA FRAGMENTATION (SDF) WAS MOST EFFECTIVELY IMPROVED BY A SPERM SEPARATION DEVICE COMPARED TO DIFFERENT GRADIENT AND SWIMUP METHODS

Broussard A., Leader B., Tirado E. et al. Fertility and Sterility. April 2019 Volume 111, Issue 4, Supplement, Page e15

View More