Publications

MICROFLUIDIC SPERM SELECTION (MFSS) IMPROVES EUPLOIDY RATES COMPARED TO DENSITY GRADIENT CENTRIFUGATION (DGC) ACROSS A BROADER PATIENT POPULATION THAT UTILIZED INTRACYTOPLASMIC SPERM INJECTION (ICSI).

Mahony, M., Hayward, B., Anderson, A., Angle, M., Hudson, C. Fertility and Sterility, Volume 120, Issue 4, Supplement, E3-E4, October 2023

MICROFLUIDIC SELECTION ENHANCES CRYOSURVIVAL OF SPERMATOZOA.

Kocur, O., Xie, P., Rosenwaks, Z., Palermo, G. Fertility and Sterility, Volume 120, Issue 4, Supplement E118–E119 October 2023

THE USE OF A NOVEL SPERM SELECTION METHOD FOR INTRAUTERINE INSEMINATION OF COUPLES WITH IDIOPATHIC INFERTILITY.

Kocur, O., De Jesus, A., Rosenwaks, Z., Palermo, G. Fertility and Sterility, Volume 120, Issue 4, Supplement E307–E308 October 2023

DOES MICROFLUIDIC-BASED SEMEN PROCESSING IMPROVE THE FUNCTIONAL QUALITY OF RECOVERED SPERM?

Ribeiro, A., Minas, A., Barradas, V., Homsi, C., Bertolla, R., Intasqui, P. Fertility and Sterility, Volume 120, Issue 4, Supplement E5–E6 October 2023

LIVE BIRTH RATE AFTER USING MICROFLUIDIC SPERM SEPARATION DEVICE FOR SPERM PREPARATION IN ALL IN- VITRO FERTILIZATION (IVF) AND INTRACYTOPLASMIC SPERM INJECTION (ICSI) CYCLES.

Kothamasu, V., Ulrich, N., Toppin, J., Williams, F. Fertility and Sterility, Volume 120, Issue 4, Supplement E296–E297 October 2023

IMPROVEMENT IN SPERM DNA FRAGMENTATION INDEX IS OBSERVED AT 15 MINUTES INCUBATION TIME BUT NOT WITH LONGER INCUBATION TIMES USING THE MICROFLUIDICS SPERM SORTING SYSTEM.

Athalye, A., Naik, N., Makwana, P., Sanap, R., Tari, P., Kamath, D., Agarwal, S., Deshmukh, S., Madon, P., Parikh, F. Fertility and Sterility, Volume 120, Issue 4, Supplement E148 October 2023

MICROFLUIDIC-BASED SPERM SELECTION: EFFECT ON SPERM DNA FRAGMENTATION AND EMBRYO DEVELOPMENT.

Pardiñas, M., de los Santos, J., Jaén, D., Bastida, A., Rivera-Egea, R., Galán, A., Insua, F., de los Santos, M. Fertility and Sterility, Volume 120, Issue 4, Supplement E294 October 2023

MICROFLUIDIC PREPARATION OF SPERMATOZOA FOR ICSI PRODUCES SIMILAR EMBRYO QUALITY TO DENSITY-GRADIENT CENTRIFUGATION: A PRAGMATIC, RANDOMIZED CONTROLLED TRIAL

Molly M. Quinn¹, Salustiano Ribeiro², Flor Juarez-Hernandez², Rhodel K. Simbulan², Liza Jalalian², Marcelle I. Cedars², and Mitchell P. Rosen^{2 1}Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, ²Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA

MICROFLUIDIC-BASED DEVICE SELECTS SPERM WITH LESS DNA DAMAGE AND HIGHER MOTILITY, WHAT ELSE?

Pardiñas ML.¹, De los Santos JM.², Viloria T.², Ortega-Jaen D.¹, Martin A.¹, Rivera-Egea R.², De los Santos MJ.^1,2, ¹IVI Foundation-IIS La Fe, Research and Innovation, Valencia, Spain, ²IVI RMA Valencia, IVF Laboratory, Valencia, Spain.

ASSESSING THE INTEGRITY OF THE MALE GAMETE GENOME TO IMPROVE ART CLINICAL OUTCOMES

Kocur OM., Xie P., Sung C., Souness S., Rosenwaks Z., Palermo GD., Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, New York, New York USA

FERTILIZATION RATE AND EMBRYONIC DEVELOPMENT AFTER INTRACYTOPLASMIC SPERM INJECTION USING A MICROFLUIDIC SPERM SELECTION DEVICE WITHOUT CENTRIFUGATION

Haruhisa Tsuji¹, Hiroya Kitasaka¹, Noritaka Fukunaga^1,2 and Yoshimasa Asada^{1,2 1} Asada Ladies Clinic, Aichi, Japan, ² Asada Institute for Reproductive Medicine, Aichi, Japan

DOES ZYMOT SPERM SEPARATION IMPROVE EMBRYO DEVELOPMENT OUTCOMES WHEN APPLIED TO ALL INFERTILITY PATIENTS COMPARED TO DENSITY GRADIENT WASHING OR SURGICALLY ATTAINED SPERM?

Mitchel C. Schiewe, MS, PhD, Ahmad Morsi Abu Maizar, M.Sc, Melanie Nordbak, BS, Michelle Alcoer, BS, Andrew W. Dinsmore, BS, Claudia De Romana, BS, Pedro J. Toledo, BS, Kelly Baek, MD, Guy E. Ringler, MD, Korine Chung, MD, Richard Marrs, MD California Fertility Partners, Los Angeles, CA

MICROFLUIDIC SORTING SELECTS SPERM FOR CLINICAL USE WITH REDUCED DNA DAMAGE

Quinn M. M., Jalalian L., Ribeiro S., et al. Human Reproduction, Volume 33, Issue 8, August 2018, Pages 1388–1393

SPERM DNA FRAGMENTATION (SDF) WAS MOST EFFECTIVELY IMPROVED BY A SPERM SEPARATION DEVICE COMPARED TO DIFFERENT GRADIENT AND SWIMUP METHODS

Broussard A., Leader B., Tirado E. et al. Fertility and Sterility. April 2019 Volume 111, Issue 4, Supplement, Page e15

MICROFLUIDIC PREPARATION OF SPERMATOZOA FOR ICSI PRODUCES SIMILAR EMBRYO QUALITY TO DENSITY-GRADIENT CENTRIFUGATION: A PRAGMATIC, RANDOMIZED CONTROLLED TRIAL

Molly M. Quinn¹, Salustiano Ribeiro², Flor Juarez-Hernandez², Rhodel K. Simbulan², Liza Jalalian², Marcelle I. Cedars², and Mitchell P. Rosen^{2 1}Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, ²Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA

MICROFLUIDIC SPERM SELECTION DEVICE INCREASES CLINICAL PREGNANCY RATE IN IVF/PGT-A CYCLES

C.Z. Berton¹, I. Yoshida¹, P. Carvalho¹, R. Souza¹, L.D.C. Onoda¹, E.B. Cordts², C.P. Barbosa². ¹Instituto Ideia Fértil de Saúde Reprodutiva, Embryology, São Paulo, Brazil, ² Instituto Ideia Fértil de Saúde Reprodutiva, Gynecology, São Paulo, Brazil.

MACS Vs MICROFLUIDICS SPERM SORTING FOR RAISED SPERM DFI - A RCT

Durga Rao, Krishna Chaitanya M., Oasis Fertility – Hyderabad, India

IMPROVING PREGNANCY RATE IN IVF CYCLES BY PREPARING SPERM VIA MICROFLUIDIC SPERM CHIPS

Alagöz O., Özkara G., Koçer Yazıcı M. G., et al. ESHRE 2017

MICROFLUIDIC SELECTION OF SPERMATOZOA RETAINS CHROMATIN INTEGRITY AND YIELDS HIGHER PREGNANCY RATES

Parrella A., Xie P., Keating D., et al. ASRM 2018

COMPARISON OF MICROFLUID SPERM SORTING CHIP AND DENSITY GRADIENT METHODS FOR USE IN INTRAUTERINE INSEMINATION CYCLES

Gode, F., Bodur T., Güntürkün F., et al. Fertility and Sterility. Volume 112, Issue 5, November 2019, Pages 842-848.e1

EUPLOIDY RATES AND PREGNANCY OUTCOMES USING THE ZYMOT DEVICE FOR SPERM PREPARATION

Anderson, Anthony R. et al. Author, ASRM

SUPERIOR SPERM SELECTION? MICROFLUIDIC SPERM SORTING IMPROVES EUPLOID EMBRYO ONGOING PREGNANCY RATE COMPARED TO DENSITY GRADIENT CENTRIFUGATION

Parrella, Alessandra. ASRM 2020

ICSI OUTCOMES USING SPERMATOZOA WITH OPTIMAL GENOMIC INTEGRITY

Parrella, Alessandra. ASRM 2020

UTILIZING SPERMATOZOA WITH THE HIGHEST GENOMIC INTEGRITY ENHANCES ICSI OUTCOME.

Keating, D., Tavares, D., Rosenwaks, Z., Palermo, G. Fertility and Sterility Vol. 116, E67-E68(2021)

SPERM DNA INTEGRITY AND MALE INFERTILITY: A NARRATIVE REVIEW AND GUIDE FOR THE REPRODUCTIVE PHYSICIANS

Farkouh A, Salvio G, Kuroda S, Saleh R, Vogiatzi P, Agarwal A. Transl Androl Urol 2022;11(7):1023-1044. DOI: 10.21037/TAU-22-149

CAN A SPERM SELECTION TECHNIQUE IMPROVE EMBRYO PLOIDY?

Olena M. Kocur, Philip Xie, Stephanie Cheung, Sydney Souness, Mary McKnight, Zev Rosenwaks, Gianpiero D. Palermo

GENOTYPIC SPERM SORTING: A LESS INVASIVE “ART” TO PREVENT GENETIC DISORDERS IN NEWBORNS

^*1,3Olumide O. Adenmosun, PhD, MBA (oadenmos@fau.edu) ²Waseem Asghar, PhD, ³Michael Matilsky, PhD, HCLD and ¹James Kumi-Diaka, DVM, PhD, ¹Florida Atlantic University, Biological Sciences, Davie, USA, ²Florida Atlantic University, Electrical Engineering and Computer Science, Boca Raton, USA, ³Boca Fertility, Andrology/Embryology Laboratory, Boca Raton, USA

MICROFLUIDIC-BASED DEVICE SELECTS SPERM WITH LESS DNA DAMAGE AND HIGHER MOTILITY, WHAT ELSE?

Pardiñas ML.¹, De los Santos JM.², Viloria T.², Ortega-Jaen D.¹, Martin A.¹, Rivera-Egea R.², De los Santos MJ.^1,2, ¹IVI Foundation-IIS La Fe, Research and Innovation, Valencia, Spain, ²IVI RMA Valencia, IVF Laboratory, Valencia, Spain.

ASSESSING THE INTEGRITY OF THE MALE GAMETE GENOME TO IMPROVE ART CLINICAL OUTCOMES

Kocur OM., Xie P., Sung C., Souness S., Rosenwaks Z., Palermo GD., Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, New York, New York USA

MALE AGE IS ASSOCIATED WITH SPERM DNA INTEGRITY: SELECTION OF HIGH DNA INTEGRITY SPERM BY MICROFLUIDICS SORTING IS CRITICAL TO CLINICAL OUTCOMES IN OLDER PATIENTS

Nami Morishita, Megumi Miura, Yuki Kobayashi, Rie Matsunaga, Tomoko Maeda, Masanori Ochi, Toshitaka Horiuchi, Ochi Yume Clinic Nagoya, Nagoya, Japan

MACS Vs MICROFLUIDICS SPERM SORTING FOR RAISED SPERM DFI - A RCT

Durga Rao, Krishna Chaitanya M., Oasis Fertility – Hyderabad, India

A TREATMENT APPROACH FOR COUPLES WITH DISRUPTED SPERM DNA INTEGRITY AND RECURRENT ART FAILURE.

Alessandra Parrella, Derek Keating, Stephanie Cheung, Philip Xie, Joshua D. Stewart, Zev Rosenwaks, Gianpiero D. Palermo Journal of Assisted Reproduction and Genetics volume 36, pages2057–2066 (2019)

A TREATMENT APPROACH FOR COUPLES WITH DISRUPTED SPERM DNA INTEGRITY AND RECURRENT ART FAILURE

Parrella, A., Keating, D., Cheung, S. et al. J Assist Reprod Genet 36, 2057–2066 (2019)

MICROFLUIDIC SPERM SEPARATION DEVICE DRAMATICALLY LOWERS DFI

Cohen,¹A. Bastuba,²P. Campbell. ^{3 1}Male Fertility and Sexual Medicine Specialists, San Diego, CA, USA; ²Fertility Center of California, San Diego, CA, USA; ³ Department of Urology, Naval Medical Center San Diego, San Diego, CA, USA.

DOES ZYMOT SPERM SEPARATION IMPROVE EMBRYO DEVELOPMENT OUTCOMES WHEN APPLIED TO ALL INFERTILITY PATIENTS COMPARED TO DENSITY GRADIENT WASHING OR SURGICALLY ATTAINED SPERM?

Mitchel C. Schiewe, MS, PhD, Ahmad Morsi Abu Maizar, M.Sc, Melanie Nordbak, BS, Michelle Alcoer, BS, Andrew W. Dinsmore, BS, Claudia De Romana, BS, Pedro J. Toledo, BS, Kelly Baek, MD, Guy E. Ringler, MD, Korine Chung, MD, Richard Marrs, MD California Fertility Partners, Los Angeles, CA

SPERM DNA FRAGMENTATION AND FUNCTIONAL FEATURES OF HUMAN SPERM SELECTED BY MICROFLUIDIC SORTING FOR CLINICAL USE

Nami Morishita, Ph.D., Natsumi Hyogo, M.A., Yukari Kurasaki, B.A., Rio Sakuma, M.A., Hiromi Morita, M.A., Megumi Miura, M.A, Yuki Kobayashi, B.A., Rie Matsunaga, M.A., Tomoko Maeda, Ph.D., Hiroshi Makino, Ph.D., Masanori Ochi, Ph.D., Toshitaka Horiuchi, Ph.D. OCHI YUME CLINIC NAGOYA, Nagoya, Japan

CAN MICROFLUIDIC SPERM SORTING HELP SEPARATION OF SPERMS WITH GOOD QUALITY DNA?

Krishna Mantravadi, Sr. MBBS, PGDHOM, Masters in clinical embryology, Durga Gedela Rao, Sr. MRCOG Oasis fertility, Hyderabad, India

SELECTION OF FUNCTIONAL HUMAN SPERM WITH HIGHER DNA INTEGRITY AND FEWER REACTIVE OXYGEN SPECIES

Asghar W., Velasco V., Kingsley J.L., et al. Advanced Healthcare Materials. Volume 3, Issue 10, October, 2014

SELECTION OF SPERMATOZOA WITH HIGHER CHROMATIN INTEGRITY THROUGH A MICROFLUIDICS DEVICE

Parrella A., Pereira N., Chow S., et al. ESHRE 2017

IMPACT OF MICROFLUIDIC SPERM SORTING ON EMBRYO QUALITY AND COMPREHENSIVE CHROMOSOME SCREENING OUTCOMES OF COUPLES WITH REPEATED IMPLANTATION FAILURE

Pabuccu E., Pabuccu R., Sertyel S., et al. ESHRE 2018

A MICROFLUIDIC DEVICE FOR SELECTING THE MOST PROGRESSIVELY MOTILE SPERMATOZOA YIELDS A HIGHER RATE OF EUPLOID EMBRYOS

Parrella A., Choi D., Keating D., et al. ASRM 2018

MICROFLUIDIC SELECTION OF SPERMATOZOA RETAINS CHROMATIN INTEGRITY AND YIELDS HIGHER PREGNANCY RATES

Parrella A., Xie P., Keating D., et al. ASRM 2018

MICROFLUIDIC SPERM SELECTION ENHANCES ICSI OUTCOMES BY SELECTING SPERMATOZOA WITH THE HIGHEST CHROMATIN INTEGRITY

Hancock K., Parrella A., Goldman M., et al. ESHRE 2019

MICROFLUIDIC SPERM SELECTION BY THE ZYMŌT SPERM SEPARATION DEVICE CONCENTRATES SPERM WITH SIGNIFICANTLY LESS DNA DAMAGE FOR SUBSEQUENT ART PROCEDURES

Hodge D., Vermilyea M., O’Leary R., et al. ESHRE 2019

A THERAPEUTIC APPROACH FOR COUPLES WITH COMPROMISED SPERM DNA INTEGRITY AND A HISTORY OF ANEUPLOID EMBRYOS

Petrini A., Parrella A., Xie P., et al. ESHRE 2019

MICROFLUIDIC DEVICE-BASED SEMEN PREPARATION INFLUENCES EUPLOIDY RATES OF HUMAN BLASTOCYSTS

Beyhan, Z. et al. ASRM 2020

SUPERIOR SPERM SELECTION? MICROFLUIDIC SPERM SORTING IMPROVES EUPLOID EMBRYO ONGOING PREGNANCY RATE COMPARED TO DENSITY GRADIENT CENTRIFUGATION

Parrella, Alessandra. ASRM 2020

ICSI OUTCOMES USING SPERMATOZOA WITH OPTIMAL GENOMIC INTEGRITY

Parrella, Alessandra. ASRM 2020

UTILIZING SPERMATOZOA WITH THE HIGHEST GENOMIC INTEGRITY ENHANCES ICSI OUTCOME.

Keating, D., Tavares, D., Rosenwaks, Z., Palermo, G. Fertility and Sterility Vol. 116, E67-E68(2021)

A SPERM SELECTION TECHNIQUE TO IMPROVE EMBRYO PLOIDY.

Keating, D., Tavares, D., Rosenwaks, Z., Palermo, G. Fertility and Sterility Vol. 116, P-53(2021)

CAN A SPERM SELECTION TECHNIQUE IMPROVE EMBRYO PLOIDY?

Olena M. Kocur, Philip Xie, Stephanie Cheung, Sydney Souness, Mary McKnight, Zev Rosenwaks, Gianpiero D. Palermo

MICROFLUIDIC PREPARATION OF SPERMATOZOA FOR ICSI PRODUCES SIMILAR EMBRYO QUALITY TO DENSITY-GRADIENT CENTRIFUGATION: A PRAGMATIC, RANDOMIZED CONTROLLED TRIAL

Molly M. Quinn¹, Salustiano Ribeiro², Flor Juarez-Hernandez², Rhodel K. Simbulan², Liza Jalalian², Marcelle I. Cedars², and Mitchell P. Rosen^{2 1}Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, ²Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA

A TREATMENT APPROACH FOR COUPLES WITH DISRUPTED SPERM DNA INTEGRITY AND RECURRENT ART FAILURE.

Alessandra Parrella, Derek Keating, Stephanie Cheung, Philip Xie, Joshua D. Stewart, Zev Rosenwaks, Gianpiero D. Palermo Journal of Assisted Reproduction and Genetics volume 36, pages2057–2066 (2019).

MICROFLUIDIC DEVICE-BASED SEMEN PREPARATION INFLUENCES EUPLOIDY RATES OF HUMAN BLASTOCYSTS.

Beyhan, Z. et al. ASRM 2020

A TREATMENT APPROACH FOR COUPLES WITH DISRUPTED SPERM DNA INTEGRITY AND RECURRENT ART FAILURE

Parrella, A., Keating, D., Cheung, S. et al. J Assist Reprod Genet 36, 2057–2066 (2019)

DOES MICROFLUIDIC SPERM SORTING IMPROVE EMBRYO DEVELOPMENT AND EUPLOIDY RATES IN PATIENTS UNDERGOING ICSI?

Alex Robles, M.D.,¹ Evan Akiva Reshef, MD,¹ Robert W. Prosser, MSc,¹Eric J. Forman, M.D.,² Zev Williams, M.D., PhD.^{1 1}Columbia University Fertility Center, New York, NY; ²Columbia University Fertility Center.

DOES ZYMOT SPERM SEPARATION IMPROVE EMBRYO DEVELOPMENT OUTCOMES WHEN APPLIED TO ALL INFERTILITY PATIENTS COMPARED TO DENSITY GRADIENT WASHING OR SURGICALLY ATTAINED SPERM?

Mitchel C. Schiewe, MS, PhD, Ahmad Morsi Abu Maizar, M.Sc, Melanie Nordbak, BS, Michelle Alcoer, BS, Andrew W. Dinsmore, BS, Claudia De Romana, BS, Pedro J. Toledo, BS, Kelly Baek, MD, Guy E. Ringler, MD, Korine Chung, MD, Richard Marrs, MD California Fertility Partners, Los Angeles, CA

A PROPOSED METHOD TO MINIMIZE MALE GAMETE CONTRIBUTION TO ANEUPLOIDY IN THE EMBRYO COHORT

Melnick A., Parrella A., Cheung S., et al. ESHRE 2018

IMPACT OF MICROFLUIDIC SPERM SORTING ON EMBRYO QUALITY AND COMPREHENSIVE CHROMOSOME SCREENING OUTCOMES OF COUPLES WITH REPEATED IMPLANTATION FAILURE

Pabuccu E., Pabuccu R., Sertyel S., et al. ESHRE 2018

A MICROFLUIDIC DEVICE FOR SELECTING THE MOST PROGRESSIVELY MOTILE SPERMATOZOA YIELDS A HIGHER RATE OF EUPLOID EMBRYOS

Parrella A., Choi D., Keating D., et al. ASRM 2018

LABORATORY AND CLINICAL OUTCOMES OF SPERMATOZA PREPARED THROUGH A MICROFLUIDIC DEVICE: A PROSPECTIVE PILOT SIBLING OOCYTE STUDY

Akcay B., Findikli N., Aksoy T., et al. ASRM 2018

EFFECTS OF THE MICROFLUIDIC CHIP TECHNIQUE IN SPERM SELECTION FOR INTRACYTOPLASMIC SPERM INJECTION FOR UNEXPLAINED INFERTILITY: A PROSPECTIVE, RANDOMIZED CONTROLLED TRIAL

Yetkinel, S., Kilicdag, E.B., Aytac, P.C. et al. J Assist Reprod Genet 36, 403–409 (2019)

A THERAPEUTIC APPROACH FOR COUPLES WITH COMPROMISED SPERM DNA INTEGRITY AND A HISTORY OF ANEUPLOID EMBRYOS

Petrini A., Parrella A., Xie P., et al. ESHRE 2019

EUPLOIDY RATES AND PREGNANCY OUTCOMES USING THE ZYMOT DEVICE FOR SPERM PREPARATION

Anderson, Anthony R. et al. Author, ASRM

EMBRYOLOGIC OUTCOMES IN INTRACYTOPLASMIC SPERM INJECTION (ICSI) CYCLES UTILIZING SPERM SELECTED VIA A MICROFLUIDICS DEVICE COMPARED TO STANDARD SELECTION

Godiwala, Prachi et al. ASRM 2020

MICROFLUIDIC SPERM SELECTION IS AN EFFECTIVE METHOD FOR IMPROVING EMBRYO DEVELOPMENTAL COMPETENCE IN IVF WITH OLDER PATIENTS

Mastunga, Rie et al. ASRM 2020

SUPERIOR SPERM SELECTION? MICROFLUIDIC SPERM SORTING IMPROVES EUPLOID EMBRYO ONGOING PREGNANCY RATE COMPARED TO DENSITY GRADIENT CENTRIFUGATION

Parrella, Alessandra. ASRM 2020

ICSI OUTCOMES USING SPERMATOZOA WITH OPTIMAL GENOMIC INTEGRITY

Parrella, Alessandra. ASRM 2020

UTILIZING SPERMATOZOA WITH THE HIGHEST GENOMIC INTEGRITY ENHANCES ICSI OUTCOME.

Keating, D., Tavares, D., Rosenwaks, Z., Palermo, G. Fertility and Sterility Vol. 116, E67-E68(2021)

A SPERM SELECTION TECHNIQUE TO IMPROVE EMBRYO PLOIDY.

Keating, D., Tavares, D., Rosenwaks, Z., Palermo, G. Fertility and Sterility Vol. 116, P-53(2021)

MICROFLUIDIC PREPARATION OF SPERMATOZOA FOR ICSI PRODUCES SIMILAR EMBRYO QUALITY TO DENSITY-GRADIENT CENTRIFUGATION: A PRAGMATIC, RANDOMIZED CONTROLLED TRIAL

Molly M. Quinn¹, Salustiano Ribeiro², Flor Juarez-Hernandez², Rhodel K. Simbulan², Liza Jalalian², Marcelle I. Cedars², and Mitchell P. Rosen^{2 1}Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, ²Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA

FERTILIZATION RATE AND EMBRYONIC DEVELOPMENT AFTER INTRACYTOPLASMIC SPERM INJECTION USING A MICROFLUIDIC SPERM SELECTION DEVICE WITHOUT CENTRIFUGATION

Haruhisa Tsuji¹, Hiroya Kitasaka¹, Noritaka Fukunaga^1,2 and Yoshimasa Asada^{1,2 1} Asada Ladies Clinic, Aichi, Japan, ² Asada Institute for Reproductive Medicine, Aichi, Japan

DOES MICROFLUIDIC SPERM SORTING IMPROVE EMBRYO DEVELOPMENT AND EUPLOIDY RATES IN PATIENTS UNDERGOING ICSI?

Alex Robles, M.D.,¹ Evan Akiva Reshef, MD,¹ Robert W. Prosser, MSc,¹Eric J. Forman, M.D.,² Zev Williams, M.D., PhD.^{1 1}Columbia University Fertility Center, New York, NY; ²Columbia University Fertility Center.

DOES ZYMOT SPERM SEPARATION IMPROVE EMBRYO DEVELOPMENT OUTCOMES WHEN APPLIED TO ALL INFERTILITY PATIENTS COMPARED TO DENSITY GRADIENT WASHING OR SURGICALLY ATTAINED SPERM?

Mitchel C. Schiewe, MS, PhD, Ahmad Morsi Abu Maizar, M.Sc, Melanie Nordbak, BS, Michelle Alcoer, BS, Andrew W. Dinsmore, BS, Claudia De Romana, BS, Pedro J. Toledo, BS, Kelly Baek, MD, Guy E. Ringler, MD, Korine Chung, MD, Richard Marrs, MD California Fertility Partners, Los Angeles, CA

SPERM DNA FRAGMENTATION AND FUNCTIONAL FEATURES OF HUMAN SPERM SELECTED BY MICROFLUIDIC SORTING FOR CLINICAL USE

Nami Morishita, Ph.D., Natsumi Hyogo, M.A., Yukari Kurasaki, B.A., Rio Sakuma, M.A., Hiromi Morita, M.A., Megumi Miura, M.A, Yuki Kobayashi, B.A., Rie Matsunaga, M.A., Tomoko Maeda, Ph.D., Hiroshi Makino, Ph.D., Masanori Ochi, Ph.D., Toshitaka Horiuchi, Ph.D. OCHI YUME CLINIC NAGOYA, Nagoya, Japan

IMPACT OF MICROFLUIDIC SPERM SORTING ON EMBRYO QUALITY AND COMPREHENSIVE CHROMOSOME SCREENING OUTCOMES OF COUPLES WITH REPEATED IMPLANTATION FAILURE

Pabuccu E., Pabuccu R., Sertyel S., et al. ESHRE 2018

A MICROFLUIDIC DEVICE FOR SELECTING THE MOST PROGRESSIVELY MOTILE SPERMATOZOA YIELDS A HIGHER RATE OF EUPLOID EMBRYOS

Parrella A., Choi D., Keating D., et al. ASRM 2018

LABORATORY AND CLINICAL OUTCOMES OF SPERMATOZA PREPARED THROUGH A MICROFLUIDIC DEVICE: A PROSPECTIVE PILOT SIBLING OOCYTE STUDY

Akcay B., Findikli N., Aksoy T., et al. ASRM 2018

EMBRYOLOGIC OUTCOMES IN INTRACYTOPLASMIC SPERM INJECTION (ICSI) CYCLES UTILIZING SPERM SELECTED VIA A MICROFLUIDICS DEVICE COMPARED TO STANDARD SELECTION

Godiwala, Prachi et al. ASRM 2020

ICSI OUTCOMES USING SPERMATOZOA WITH OPTIMAL GENOMIC INTEGRITY

Parrella, Alessandra. ASRM 2020

UTILIZING SPERMATOZOA WITH THE HIGHEST GENOMIC INTEGRITY ENHANCES ICSI OUTCOME.

Keating, D., Tavares, D., Rosenwaks, Z., Palermo, G. Fertility and Sterility Vol. 116, E67-E68(2021)

CAN A SPERM SELECTION TECHNIQUE IMPROVE EMBRYO PLOIDY?

Olena M. Kocur, Philip Xie, Stephanie Cheung, Sydney Souness, Mary McKnight, Zev Rosenwaks, Gianpiero D. Palermo

MICROFLUIDIC PREPARATION OF SPERMATOZOA FOR ICSI PRODUCES SIMILAR EMBRYO QUALITY TO DENSITY-GRADIENT CENTRIFUGATION: A PRAGMATIC, RANDOMIZED CONTROLLED TRIAL

Molly M. Quinn¹, Salustiano Ribeiro², Flor Juarez-Hernandez², Rhodel K. Simbulan², Liza Jalalian², Marcelle I. Cedars², and Mitchell P. Rosen^{2 1}Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, ²Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA

COMPARISON OF MICROFLUID SPERM SORTING CHIP AND DENSITY GRADIENT METHODS FOR USE IN INTRAUTERINE INSEMINATION CYCLES

Gode, F., Bodur T., Güntürkün F., et al. Fertility and Sterility. Volume 112, Issue 5, November 2019, Pages 842-848.e1

CAN A SPERM SELECTION TECHNIQUE IMPROVE EMBRYO PLOIDY?

Olena M. Kocur, Philip Xie, Stephanie Cheung, Sydney Souness, Mary McKnight, Zev Rosenwaks, Gianpiero D. Palermo

MICROFLUIDIC PREPARATION OF SPERMATOZOA FOR ICSI PRODUCES SIMILAR EMBRYO QUALITY TO DENSITY-GRADIENT CENTRIFUGATION: A PRAGMATIC, RANDOMIZED CONTROLLED TRIAL

Molly M. Quinn¹, Salustiano Ribeiro², Flor Juarez-Hernandez², Rhodel K. Simbulan², Liza Jalalian², Marcelle I. Cedars², and Mitchell P. Rosen^{2 1}Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, ²Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA

OPTIMIZING SPERM SELECTION AND REPRODUCTIVE OUTCOMES BY MICROFLUIDICS FOR COUPLES WITH RAISED DFI

G. Gedela, Durga Rao, Krishna Chaitanya M., Oasis Fertility – Hyderabad, India

MALE AGE IS ASSOCIATED WITH SPERM DNA INTEGRITY: SELECTION OF HIGH DNA INTEGRITY SPERM BY MICROFLUIDICS SORTING IS CRITICAL TO CLINICAL OUTCOMES IN OLDER PATIENTS

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EUPLOIDY RATES AND PREGNANCY OUTCOMES USING THE ZYMOT DEVICE FOR SPERM PREPARATION

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